Evidence based research, product development and information are cornerstones of BioSense Solutions. We work continuously with our customers and partners in the scientific communities, supporting new discoveries documented through publications in respected international journals. Look at the references below to read the peer reviewed articles providing scientific evidence for the oCelloScope, and join us in a cooperation for generating and documenting new scientific findings.

 

2019

Immunomodulatory potential of Nisin A with application in wound healing 

Mouritzen, M. V., Andrea, A., Qvist, K., Poulsen, S. S., & Jenssen, H. (2019).

Wound Repair and Regeneration. Read more

 

Fusaoctaxin A, an example of a two-step mechanism for non-ribosomal peptide assembly and maturation in fungi

Westphal, K. R., Nielsen, K. A. H., Wollenberg, R. D., Møllehøj, M. B., Bachleitner, S., Studt, L., … & Sondergaard, T. E. (2019).

Toxins, 11(5), 277. Read more

 

KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

Mousavi, N., Truelsen, S. L. B., Hagel, G., Jorgensen, L. N., Harling, H., Timmermans, V., … & Thastrup, J. (2019).

International journal of experimental pathology. Read more

 

Advances in Rapid Detection and Antimicrobial Susceptibility Tests: A Review

Mishra, P., Mishra, K. P., Singh, D., Ganju, L., Kumar, B., & Singh, S. B. (2019).

Defence Life Science Journal, 4(1), 12-20. Read more

 

2018

In Vitro Interaction Between Macrophages And Cubosomes For Oral Vaccine Delivery Imaged By Coherent Anti-stokes Raman Scattering (CARS) And Automated Microscopy

Nielsen, L. H., Bargholz, M. T., Saarinen, J., von Halling Laier, C., Ilchenko, O., Isomäki, A. O., … & Strachan, C. J. (2018).

In Controlled Release Society Annual Meeting & Exposition 2018. Read more

 

Rapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screening

McLaughlin, H. P., & Sue, D. (2018).

BMC microbiology, 18(1), 218. Read more

 

Analysis of Whole-Genome Sequences for the Prediction of Penicillin Resistance and β-Lactamase Activity in Bacillus anthracis

Gargis, A. S., McLaughlin, H. P., Conley, A. B., Lascols, C., Michel, P. A., Gee, J. E., … & Weigel, L. M. (2018).

mSystems, 3(6), e00154-18. Read more

 

Phenotypic antibiotic susceptibility testing of pathogenic bacteria using photonic readout methods: recent achievements and impact

Tannert, A., Grohs, R., Popp, J., & Neugebauer, U. (2018).

Applied Microbiology and Biotechnology, 1-18. Read more

 

Innovations in Antimicrobial Stewardship

Bal, A. M., & Gould, I. M. (2018).

In Advanced Techniques in Diagnostic Microbiology (pp. 699-710). Springer, Cham. Read more

 

FlbA-regulated gene rpnR is involved in stress resistance and impacts protein secretion when Aspergillus niger is grown on xylose

Aerts, D., van den Bergh, S. G., Post, H., Altelaar, M. A., Arentshorst, M., Ram, A. F., Ohm, R. A., & Wösten, H. A. (2018).

Appl. Environ. Microbiol., AEM-02282. Read more

 

Advances in online methods for monitoring microbial growth.

Zhang, X., Jiang, X., Hao, Z., & Qu, K. (2018).

Biosensors and Bioelectronics. Read more

 

Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.

Ashley, N., Ouaret, D., & Bodmer, W. F. (2018).

The Journal of pathology. Read more

 

Optimized Scratch Assay for In Vitro Testing of Cell Migration with an Automated Optical Camera.

Mouritzen, M. V., & Jenssen, H. (2018).

JoVE (Journal of Visualized Experiments), (138), e57691-e57691. Read more

 

Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures.

McNair, L. K., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Garrigues, C., Jäger, A. K., Franzyk, H. & Staerk, D. (2018).

FEMS Yeast Research. Read more

 

Molecular mechanisms of thioridazine resistance in Staphylococcus aureus

Wassmann, C. S., Lund, L. C., Thorsing, M., Lauritzen, S. P., Kolmos, H. J., Kallipolitis, B. H., & Klitgaard, J. K. (2018).

PloS one, 13(8), e0201767. Read more

 

Quorum Sensing Modulates the Epibiotic-Parasitic Relationship Between Actinomyces odontolyticus and Its Saccharibacteria epibiont, a Nanosynbacter lyticus Strain, TM7x

Bedree, J. K., Bor, B., Cen, L., Edlund, A., Lux, R., McLean, J. S., Shi, W., & He, X. (2018).

Frontiers in microbiology, 9. Read more

 

Identification and antibiotic‐susceptibility profiling of infectious bacterial agents: a review of current and future trends

Maugeri, G., Lychko, I., Sobral, R., & Roque, A. C. A. (2018).

Biotechnology journal, 1700750. Read more

 

Combined detection of C-reactive protein and PBMC quantification from whole blood in an integrated lab-on-a-disc microfluidic platform

Uddin, R., Donolato, M., Hwu, E. T., Hansen, M. F., & Boisen, A. (2018).

Sensors and Actuators B: Chemical. Read more

 

In vitro methods to assess drug precipitation in the fasted small intestine–a PEARRL review

O’Dwyer, P. J., Litou, C., Box, K. J., Dressman, J. B., Kostewicz, E. S., Kuentz, M., & Reppas, C. (2018).

Journal of Pharmacy and Pharmacology. Read more

 

Neurotensin, substance P, and insulin enhance cell migration.

Mouritzen, M. V., Abourayale, S., Ejaz, R., Ardon, C. B., Carvalho, E., Dalgaard, L. T.,  Roursgaard, M., & Jenssen, H. (2018).

Journal of Peptide Science, e3093. Read more

 

LL‐37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line

Saporito, P., Vang Mouritzen, M., Løbner‐Olesen, A., & Jenssen, H. (2018).

Journal of Peptide Science, e3080 Read more

 

Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids

van der Hee, B., Loonen, L. M. P., Taverne, N., Taverne-Thiele, J. J., Smidt, H., & Wells, J. M. (2018).

Stem Cell Research  Read more

 

Real-Time Digital Bright Field Technology for Rapid Antibiotic Susceptibility Testing

Canali, C., Spillum, E., Valvik, M., Agersnap, N., & Olesen, T. (2018).

Antibiotic Resistance Protocols (pp. 75-84). Humana Press, New York, NY  Read more

 

2017

Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH.

Kristensen, M., Nielsen, L. H., Zór, K., Boisen, A., Christensen, M. V., Berthelsen, J., & Mørck Nielsen, H. (2017).

Bioconjugate Chemistry. Read more

 

The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.

Christiansen, S. H., Murphy, R. A., Juul-Madsen, K., Fredborg, M., Hvam, M. L., Axelgaard, E., … & Nyengaard, J. R. (2017).

Scientific Reports, 7(1), 15653. Read more

 

Combining diagnostic methods for antimicrobial susceptibility testing–A comparative approach

Kłodzińska, S. N., Priemel, P. A., Rades, T., & Nielsen, H. M. (2017).

Journal of Microbiological Methods. Read more

 

Automated time-lapse microscopy a novel method for screening of antibiotic combination effects against multidrug-resistant Gram-negative bacteria.

Ungphakorn, W., Lagerbäck, P., Nielsen, E. I., & Tängdén, T. (2017).

Clinical Microbiology and Infection. Read more

 

Imaging for monitoring downstream processing of fermentation broths.

Moiseyenko, R., Baum, A., Jørgensen, T. M., Glanville, S., Laursen, C. N., Mansouri, S. S., & Gernaey, K. V. (2017).

In Recent Advances in Fermentation Technology (RAFT 2017). Read more

 

Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine.

Jeppesen, M., Hagel, G., Glenthoj, A., Vainer, B., Ibsen, P., Harling, H., Thastrup, O., Jørgensen, L. & Thastrup, J. (2017).

PloS one. Read more

 

Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing.

Li, Y., Yang, X., & Zhao, W. (2017).

SLAS TECHNOLOGY: Translating Life Sciences Innovation. Read more

 

New evidence for the mechanism of action of a type-2 diabetes drug using a magnetic bead-based automated biosensing platform.

Uddin, R., Habiba, N. E., Rena, G., Hwu, E. T., & Boisen, A. (2017).

ACS sensors. Read more

 

Development of a video-microscopic tool to evaluate the precipitation kinetics of poorly-water soluble drugs: A case study with tadalafil and HPMC

Christfort, J. F., Plum, J., Madsen, C. M., Nielsen, L. H., Sandau, M., Andersen, K., Müllertz, A., & Rades, T. (2017).

Molecular Pharmaceutics. Read more

 

Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci

Rasmussen, K. S., Poulsen, M. Ø., Jacobsen, K., Skov, M. N., Kolmos, H. J., Kallipolitis, B. H., & Klitgaard, J. K. (2017).

The new microbiologica, 40(2). Read more

 

Synergistic activities of meropenem double and triple combinations against carbapenemase-producing Enterobacteriaceae

Fredborg, M., Sondergaard, T. E., & Wang, M. (2017).

Diagnostic Microbiology and Infectious Disease. Read more

 

Optical screening for rapid antimicrobial susceptibility testing and for observation of phenotypic diversity among strains of the genetically clonal species Bacillus anthracis

McLaughlin HP, Gargis AS, Michel P, Sue D, Weigel LM. (2017).

J Clin Microbiol 55:959–970. Read more

 

New and developing diagnostic technologies for urinary tract infections

Davenport, M., Mach, K. E., Shortliffe, L. M. D., Banaei, N., Wang, T. H., & Liao, J. C. (2017).

Nature Reviews Urology. Read more:

 

Current and emerging techniques for antibiotic susceptibility tests

Syal K, Mo M, Yu H, Iriya R, Jing W, Guodong S, Wang S, Grys TE, Haydel SE, Tao N.

Theranostics 2017; 7(7):1795-1805. Read more:

 

Maturation of conidia on conidiophores of Aspergillus niger

Teertstra, W. R., Tegelaar, M., Dijksterhuis, J., Golovina, E. A., Ohm, R. A., & Wösten, H. A. (2017).

Fungal Genetics and Biology, 98, 61-70. Read more:

 

Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

Ungphakorn, W., Malmberg, C., Lagerbäck, P., Cars, O., Nielsen, E. I., & Tängdén, T. (2017).

Journal of Microbiological Methods, 132, 69-75. Read more:

 

2016

Fast Screening of Antibacterial Compounds from Fusaria

Sondergaard, T. E., Fredborg, M., Oppenhagen Christensen, A. M., Damsgaard, S. K., Kramer, N. F., Giese, H., & Sørensen, J. L. (2016).

Toxins, 8(12), 355. Read more:

 

Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium

Wollenberg, R. D., Donau, S. S., Nielsen, T. T., Sørensen, J. L., Giese, H., Wimmer, R., & Søndergaard, T. E. (2016).

Pesticide Biochemistry and Physiology, 134, 24-30. Read more:

 

Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture

Pijuan-Galitó, S., Tamm, C., Schuster, J., Sobol, M., Forsberg, L., Merry, C. L., & Annerén, C. (2016).

Nature Communications, 7: 12170. Read more:

 

Lab-on-a-disc agglutination assay for protein detection by optomagnetic readout and optical imaging using nano-and micro-sized magnetic beads

Uddin, R., Burger, R., Donolato, M., Fock, J., Creagh, M., Hansen, M. F., & Boisen, A. (2016).

Biosensors and Bioelectronics, 85, 351-357. Read more:

 

The In Vitro Redundant Enzymes PurN and PurT are both essential for systemic infection of mice in Salmonella enterica serovar Typhimurium

Jelsbak, L., Mortensen, M. I., Kilstrup, M., & Olsen, J. E. (2016).

Infection and immunity, 84(7), 2076-2085. Read more:

 

2015

Integration of agglutination assay for protein detection in microfluidic disc using Blu-ray optical pickup unit and optical fluid scanning

Uddin, R., Burger, R., Donolato, M., Fock, J., Creagh, M., Hansen, M. F., & Boisen, A. (2015).

Proceedings of Microtas 2015, Gyeongju, Korea. Read more:

 

Real-time monitoring of fungal inhibition and morphological changes

Aunsbjerg, S. D., Andersen, K. R., & Knøchel, S. (2015).

Journal of microbiological methods, 119, 196-202. Read more:

 

Automated image analysis for quantification of filamentous bacteria

Fredborg, M., Rosenvinge, F. S., Spillum, E., Kroghsbo, S., Wang, M., & Sondergaard, T. E. (2015).

BMC microbiology, 15(1), 255. Read more:

 

Rapid antimicrobial susceptibility testing of clinical isolates by digital time-lapse microscopy

Fredborg, M., Rosenvinge, F. S., Spillum, E., Kroghsbo, S., Wang, M., & Sondergaard, T. E. (2015).

European Journal of Clinical Microbiology & Infectious Diseases, 34(12), 2385-2394. Read more:

 

Extended spectrum β-lactamase-producing E. coli forms filaments as an initial response to cefotaxime treatment

Kjeldsen, T. S., Sommer, M. O., & Olsen, J. E. (2015).

BMC microbiology, 15(1), 63. Read more:

 

Rational design of Alpha-Helical Antimicrobial Peptides: Dos and Don’ts

Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt‐Moller, N., Hansen, P. R., & Wimmer, R. (2015).

ChemBioChem, 16(2), 242-253. Read more:

 

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, D. D., Lagerbäck, P., Cao, S., Lustig, U., Nielsen, E. I., Cars, O., Hughes, D., Andersson, D. I., & Friberg, L. E. (2015).

Journal of Antimicrobial Chemotherapy, 70(11), 3051-3060. Read more:

 

2014

Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays

Ashley, N., Jones, M., Ouaret, D., Wilding, J., & Bodmer, W. F. (2014).

The Journal of pathology, 234(1), 34-45. Read more:

 

Complete sequences of IncHI1 plasmids carrying blaCTX-M-1 and qnrS1 in equine Escherichia coli provide new insights into plasmid evolution

Dolejska, M., Villa, L., Minoia, M., Guardabassi, L., & Carattoli, A. (2014)

Journal of Antimicrobial Chemotherapy, 69(9): 2388-93. Read more:

 

Identification of the Biosynthetic Gene Clusters for the Lipopeptides Fusaristatin A and W493 B in Fusarium graminearum and F. pseudograminearum

Sørensen, J. L., Sondergaard, T. E., Covarelli, L., Fuertes, P. R., Hansen, F. T., Frandsen, R. J. N., Saei, W., Lukassen, M. B., Wimmer, R., Nielsen, K. F., Gardiner, D. M., & Giese, H. (2014)

Journal of natural products, 77(12), 2619-2625. Read more: 

 

2013

Real-time optical antimicrobial susceptibility testing

Fredborg, M., Andersen, K. R., Jørgensen, E., Droce, A., Olesen, T., Jensen, B. B., Rosenvinge, F. S., & Sondergaard, T. E. (2013)

Journal of clinical microbiology, 51(7), 2047-2053. Read more: