Evidence based research, product development and information are cornerstones of BioSense Solutions. We work continuously with our customers and partners in the scientific communities, supporting new discoveries documented through publications in respected international journals. Look at the references below to read the peer reviewed articles providing scientific evidence for the oCelloScope, and join us in a cooperation for generating and documenting new scientific findings.



How preclinical infection models help define antibiotic doses in the clinic.

Tängdén, T., Lundberg, C. V., Friberg, L. E., & Huttner, A. (2020).

International Journal of Antimicrobial Agents, 106008. Read more


Current and near-future technologies for antibiotic susceptibility testing and resistant bacteria detection

Dietvorst, J., Vilaplana, L., Uria, N., Marco, M. P., & Muñoz-Berbel, X. (2020).

TrAC Trends in Analytical Chemistry, 115891. Read more


Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Wistrand-Yuen, P., Olsson, A., Skarp, K., Friberg, L. E., Nielsen, E. I., Lagerbäck, P., & Tängdén, T. (2020).

Clinical Microbiology and Infection. Read more


Evaluation of the efficacy of antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa in automated time-lapse microscopy and static time-kill experiments

Olsson, A., Wistrand-Yuen, P., Nielsen, E. I., Friberg, L. E., Sandegren, L., Lagerbäck, P., & Tängdén, T. (2020).

Antimicrobial Agents and Chemotherapy. Read more


Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria

Wassmann, C.S., Højrup, P. & Klitgaard, J.K. (2020)

Scientific reports 104112. Read more


Insights Obtained by Culturing Saccharibacteria With Their Bacterial Hosts

Bor, B., Collins, A. J., Murugkar, P. P., Balasubramanian, S., To, T. T., Hendrickson, E. L., … & McLean, J. S. (2020).

Journal of Dental Research, 0022034520905792. Read more


Screening for double carbapenem therapies effective against multidrug resistant Enterobacteriaceae

Vickberg, K. (2019)

Master thesis, Uppsala University, Department of Medical Biochemistry and Microbiology. Read more


Bacterial Flow Cytometry and Imaging as Potential Process Monitoring Tools for Industrial Biotechnology

Narayana, S. K., Mallick, S., Siegumfeldt, H., & van den Berg, F. (2020).

Fermentation6(1), 10. cRead more



Growth and single cell kinetics of the loricate choanoflagellate Diaphanoeca grandis

Eriksen, N. T., Tophøj, J., Wollenberg, R. D., Sondergaard, T. E., Funch, P., & Andersen, P. (2019).

Scientific reports9(1), 1-12. Read more


Evaluation of the inhibitory effect of alginate oligosaccharide on yeast and mould in yoghurt

Bouillon, G., Gåserød, O., & Rattray, F. P. (2019).

International Dairy Journal. Read more


The most heat‐resistant conidia observed to date are formed by distinct strains of Paecilomyces variotii

van den Brule, T., Punt, M., Teertstra, W., Houbraken, J., Wösten, H., & Dijksterhuis, J. (2019).

Environmental microbiology. Read more


Immunomodulatory potential of Nisin A with application in wound healing 

Mouritzen, M. V., Andrea, A., Qvist, K., Poulsen, S. S., & Jenssen, H. (2019).

Wound Repair and Regeneration. Read more


Fusaoctaxin A, an example of a two-step mechanism for non-ribosomal peptide assembly and maturation in fungi

Westphal, K. R., Nielsen, K. A. H., Wollenberg, R. D., Møllehøj, M. B., Bachleitner, S., Studt, L., … & Sondergaard, T. E. (2019).

Toxins11(5), 277. Read more


KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

Mousavi, N., Truelsen, S. L. B., Hagel, G., Jorgensen, L. N., Harling, H., Timmermans, V., … & Thastrup, J. (2019).

International journal of experimental pathologyRead more


Advances in Rapid Detection and Antimicrobial Susceptibility Tests: A Review

Mishra, P., Mishra, K. P., Singh, D., Ganju, L., Kumar, B., & Singh, S. B. (2019).

Defence Life Science Journal, 4(1), 12-20Read more



In Vitro Interaction Between Macrophages And Cubosomes For Oral Vaccine Delivery Imaged By Coherent Anti-stokes Raman Scattering (CARS) And Automated Microscopy

Nielsen, L. H., Bargholz, M. T., Saarinen, J., von Halling Laier, C., Ilchenko, O., Isomäki, A. O., … & Strachan, C. J. (2018).

In Controlled Release Society Annual Meeting & Exposition 2018Read more


Rapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screening

McLaughlin, H. P., & Sue, D. (2018).

BMC microbiology, 18(1), 218. Read more


Analysis of Whole-Genome Sequences for the Prediction of Penicillin Resistance and β-Lactamase Activity in Bacillus anthracis

Gargis, A. S., McLaughlin, H. P., Conley, A. B., Lascols, C., Michel, P. A., Gee, J. E., … & Weigel, L. M. (2018).

mSystems, 3(6), e00154-18. Read more


Phenotypic antibiotic susceptibility testing of pathogenic bacteria using photonic readout methods: recent achievements and impact

Tannert, A., Grohs, R., Popp, J., & Neugebauer, U. (2018).

Applied Microbiology and Biotechnology, 1-18. Read more


Innovations in Antimicrobial Stewardship

Bal, A. M., & Gould, I. M. (2018).

In Advanced Techniques in Diagnostic Microbiology (pp. 699-710). Springer, Cham. Read more


FlbA-regulated gene rpnR is involved in stress resistance and impacts protein secretion when Aspergillus niger is grown on xylose

Aerts, D., van den Bergh, S. G., Post, H., Altelaar, M. A., Arentshorst, M., Ram, A. F., Ohm, R. A., & Wösten, H. A. (2018).

Appl. Environ. Microbiol., AEM-02282. Read more


Advances in online methods for monitoring microbial growth.

Zhang, X., Jiang, X., Hao, Z., & Qu, K. (2018).

Biosensors and BioelectronicsRead more


Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.

Ashley, N., Ouaret, D., & Bodmer, W. F. (2018).

The Journal of pathologyRead more


Optimized Scratch Assay for In Vitro Testing of Cell Migration with an Automated Optical Camera.

Mouritzen, M. V., & Jenssen, H. (2018).

JoVE (Journal of Visualized Experiments), (138), e57691-e57691Read more


Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures.

McNair, L. K., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Garrigues, C., Jäger, A. K., Franzyk, H. & Staerk, D. (2018).

FEMS Yeast ResearchRead more


Molecular mechanisms of thioridazine resistance in Staphylococcus aureus

Wassmann, C. S., Lund, L. C., Thorsing, M., Lauritzen, S. P., Kolmos, H. J., Kallipolitis, B. H., & Klitgaard, J. K. (2018).

PloS one, 13(8), e0201767Read more


Quorum Sensing Modulates the Epibiotic-Parasitic Relationship Between Actinomyces odontolyticus and Its Saccharibacteria epibiont, a Nanosynbacter lyticus Strain, TM7x

Bedree, J. K., Bor, B., Cen, L., Edlund, A., Lux, R., McLean, J. S., Shi, W., & He, X. (2018).

Frontiers in microbiology9Read more


Identification and antibiotic‐susceptibility profiling of infectious bacterial agents: a review of current and future trends

Maugeri, G., Lychko, I., Sobral, R., & Roque, A. C. A. (2018).

Biotechnology journal, 1700750Read more


Combined detection of C-reactive protein and PBMC quantification from whole blood in an integrated lab-on-a-disc microfluidic platform

Uddin, R., Donolato, M., Hwu, E. T., Hansen, M. F., & Boisen, A. (2018).

Sensors and Actuators B: ChemicalRead more


In vitro methods to assess drug precipitation in the fasted small intestine–a PEARRL review

O’Dwyer, P. J., Litou, C., Box, K. J., Dressman, J. B., Kostewicz, E. S., Kuentz, M., & Reppas, C. (2018).

Journal of Pharmacy and PharmacologyRead more


Neurotensin, substance P, and insulin enhance cell migration.

Mouritzen, M. V., Abourayale, S., Ejaz, R., Ardon, C. B., Carvalho, E., Dalgaard, L. T.,  Roursgaard, M., & Jenssen, H. (2018).

Journal of Peptide Science, e3093. Read more


LL‐37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line

Saporito, P., Vang Mouritzen, M., Løbner‐Olesen, A., & Jenssen, H. (2018).

Journal of Peptide Science, e3080 Read more


Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids

van der Hee, B., Loonen, L. M. P., Taverne, N., Taverne-Thiele, J. J., Smidt, H., & Wells, J. M. (2018).

Stem Cell Research  Read more


Real-Time Digital Bright Field Technology for Rapid Antibiotic Susceptibility Testing

Canali, C., Spillum, E., Valvik, M., Agersnap, N., & Olesen, T. (2018).

Antibiotic Resistance Protocols (pp. 75-84). Humana Press, New York, NY  Read more



Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH.

Kristensen, M., Nielsen, L. H., Zór, K., Boisen, A., Christensen, M. V., Berthelsen, J., & Mørck Nielsen, H. (2017).

Bioconjugate ChemistryRead more


The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.

Christiansen, S. H., Murphy, R. A., Juul-Madsen, K., Fredborg, M., Hvam, M. L., Axelgaard, E., … & Nyengaard, J. R. (2017).

Scientific Reports, 7(1), 15653. Read more


Combining diagnostic methods for antimicrobial susceptibility testing–A comparative approach

Kłodzińska, S. N., Priemel, P. A., Rades, T., & Nielsen, H. M. (2017).

Journal of Microbiological MethodsRead more


Automated time-lapse microscopy a novel method for screening of antibiotic combination effects against multidrug-resistant Gram-negative bacteria.

Ungphakorn, W., Lagerbäck, P., Nielsen, E. I., & Tängdén, T. (2017).

Clinical Microbiology and InfectionRead more


Imaging for monitoring downstream processing of fermentation broths.

Moiseyenko, R., Baum, A., Jørgensen, T. M., Glanville, S., Laursen, C. N., Mansouri, S. S., & Gernaey, K. V. (2017).

In Recent Advances in Fermentation Technology (RAFT 2017)Read more


Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine.

Jeppesen, M., Hagel, G., Glenthoj, A., Vainer, B., Ibsen, P., Harling, H., Thastrup, O., Jørgensen, L. & Thastrup, J. (2017).

PloS one. Read more


Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing.

Li, Y., Yang, X., & Zhao, W. (2017).

SLAS TECHNOLOGY: Translating Life Sciences Innovation. Read more


New evidence for the mechanism of action of a type-2 diabetes drug using a magnetic bead-based automated biosensing platform.

Uddin, R., Habiba, N. E., Rena, G., Hwu, E. T., & Boisen, A. (2017).

ACS sensors. Read more


Development of a video-microscopic tool to evaluate the precipitation kinetics of poorly-water soluble drugs: A case study with tadalafil and HPMC

Christfort, J. F., Plum, J., Madsen, C. M., Nielsen, L. H., Sandau, M., Andersen, K., Müllertz, A., & Rades, T. (2017).

Molecular Pharmaceutics. Read more


Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci

Rasmussen, K. S., Poulsen, M. Ø., Jacobsen, K., Skov, M. N., Kolmos, H. J., Kallipolitis, B. H., & Klitgaard, J. K. (2017).

The new microbiologica, 40(2). Read more


Synergistic activities of meropenem double and triple combinations against carbapenemase-producing Enterobacteriaceae

Fredborg, M., Sondergaard, T. E., & Wang, M. (2017).

Diagnostic Microbiology and Infectious Disease. Read more


Optical screening for rapid antimicrobial susceptibility testing and for observation of phenotypic diversity among strains of the genetically clonal species Bacillus anthracis

McLaughlin HP, Gargis AS, Michel P, Sue D, Weigel LM. (2017).

J Clin Microbiol 55:959–970. Read more


New and developing diagnostic technologies for urinary tract infections

Davenport, M., Mach, K. E., Shortliffe, L. M. D., Banaei, N., Wang, T. H., & Liao, J. C. (2017).

Nature Reviews Urology. Read more:


Current and emerging techniques for antibiotic susceptibility tests

Syal K, Mo M, Yu H, Iriya R, Jing W, Guodong S, Wang S, Grys TE, Haydel SE, Tao N.

Theranostics 2017; 7(7):1795-1805. Read more:


Maturation of conidia on conidiophores of Aspergillus niger

Teertstra, W. R., Tegelaar, M., Dijksterhuis, J., Golovina, E. A., Ohm, R. A., & Wösten, H. A. (2017).

Fungal Genetics and Biology, 98, 61-70. Read more:


Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

Ungphakorn, W., Malmberg, C., Lagerbäck, P., Cars, O., Nielsen, E. I., & Tängdén, T. (2017).

Journal of Microbiological Methods, 132, 69-75. Read more:



Fast Screening of Antibacterial Compounds from Fusaria

Sondergaard, T. E., Fredborg, M., Oppenhagen Christensen, A. M., Damsgaard, S. K., Kramer, N. F., Giese, H., & Sørensen, J. L. (2016).

Toxins, 8(12), 355. Read more:


Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium

Wollenberg, R. D., Donau, S. S., Nielsen, T. T., Sørensen, J. L., Giese, H., Wimmer, R., & Søndergaard, T. E. (2016).

Pesticide Biochemistry and Physiology, 134, 24-30. Read more:


Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture

Pijuan-Galitó, S., Tamm, C., Schuster, J., Sobol, M., Forsberg, L., Merry, C. L., & Annerén, C. (2016).

Nature Communications, 7: 12170. Read more:


Lab-on-a-disc agglutination assay for protein detection by optomagnetic readout and optical imaging using nano-and micro-sized magnetic beads

Uddin, R., Burger, R., Donolato, M., Fock, J., Creagh, M., Hansen, M. F., & Boisen, A. (2016).

Biosensors and Bioelectronics, 85, 351-357. Read more:


The In Vitro Redundant Enzymes PurN and PurT are both essential for systemic infection of mice in Salmonella enterica serovar Typhimurium

Jelsbak, L., Mortensen, M. I., Kilstrup, M., & Olsen, J. E. (2016).

Infection and immunity, 84(7), 2076-2085. Read more:



Integration of agglutination assay for protein detection in microfluidic disc using Blu-ray optical pickup unit and optical fluid scanning

Uddin, R., Burger, R., Donolato, M., Fock, J., Creagh, M., Hansen, M. F., & Boisen, A. (2015).

Proceedings of Microtas 2015, Gyeongju, Korea. Read more:


Real-time monitoring of fungal inhibition and morphological changes

Aunsbjerg, S. D., Andersen, K. R., & Knøchel, S. (2015).

Journal of microbiological methods, 119, 196-202. Read more:


Automated image analysis for quantification of filamentous bacteria

Fredborg, M., Rosenvinge, F. S., Spillum, E., Kroghsbo, S., Wang, M., & Sondergaard, T. E. (2015).

BMC microbiology, 15(1), 255. Read more:


Rapid antimicrobial susceptibility testing of clinical isolates by digital time-lapse microscopy

Fredborg, M., Rosenvinge, F. S., Spillum, E., Kroghsbo, S., Wang, M., & Sondergaard, T. E. (2015).

European Journal of Clinical Microbiology & Infectious Diseases, 34(12), 2385-2394. Read more:


Extended spectrum β-lactamase-producing E. coli forms filaments as an initial response to cefotaxime treatment

Kjeldsen, T. S., Sommer, M. O., & Olsen, J. E. (2015).

BMC microbiology, 15(1), 63. Read more:


Rational design of Alpha-Helical Antimicrobial Peptides: Dos and Don’ts

Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt‐Moller, N., Hansen, P. R., & Wimmer, R. (2015).

ChemBioChem, 16(2), 242-253. Read more:


A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, D. D., Lagerbäck, P., Cao, S., Lustig, U., Nielsen, E. I., Cars, O., Hughes, D., Andersson, D. I., & Friberg, L. E. (2015).

Journal of Antimicrobial Chemotherapy, 70(11), 3051-3060. Read more:



Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays

Ashley, N., Jones, M., Ouaret, D., Wilding, J., & Bodmer, W. F. (2014).

The Journal of pathology, 234(1), 34-45. Read more:


Complete sequences of IncHI1 plasmids carrying blaCTX-M-1 and qnrS1 in equine Escherichia coli provide new insights into plasmid evolution

Dolejska, M., Villa, L., Minoia, M., Guardabassi, L., & Carattoli, A. (2014)

Journal of Antimicrobial Chemotherapy, 69(9): 2388-93. Read more:


Identification of the Biosynthetic Gene Clusters for the Lipopeptides Fusaristatin A and W493 B in Fusarium graminearum and F. pseudograminearum

Sørensen, J. L., Sondergaard, T. E., Covarelli, L., Fuertes, P. R., Hansen, F. T., Frandsen, R. J. N., Saei, W., Lukassen, M. B., Wimmer, R., Nielsen, K. F., Gardiner, D. M., & Giese, H. (2014)

Journal of natural products, 77(12), 2619-2625. Read more: 



Real-time optical antimicrobial susceptibility testing

Fredborg, M., Andersen, K. R., Jørgensen, E., Droce, A., Olesen, T., Jensen, B. B., Rosenvinge, F. S., & Sondergaard, T. E. (2013)

Journal of clinical microbiology, 51(7), 2047-2053. Read more: