Evidence based research, product development and information are cornerstones of BioSense Solutions. We work continuously with our customers and partners in the scientific communities, supporting new discoveries documented through publications in respected international journals. Look at the references below to read the peer reviewed articles providing scientific evidence for the oCelloScope, and join us in a cooperation for generating and documenting new scientific findings.
2021
Physiological responses of Aspergillus niger challenged with itraconazole
Poulsen, J. S., Madsen, A. M., White, J. K., Nielsen, J. L. (2021)
Antimicrobial Agents and Chemotherapy, April 2021. Read more
The Phosphoarginine Phosphatase PtpB from Staphylococcus aureus Is Involved in Bacterial Stress Adaptation during Infection
Elhawy, M. I., Huc-Brandt, S., Pätzold, L., Gannoun-Zaki, L., Abdrabou, A, M, M., Bischoff, M., Molle, V. (2021)
Cells, 10. Read more
Sensitivity of Molds From Spoiled Dairy Products Towards Bioprotective Lactic Acid Bacteria Cultures
Shi, C., Knøchel, S. (2021)
Frontiers in Microbiology, 12. Read more
Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota
Mouritzen, V.M., Petkovic, M., Qvist, K., Poulsen, S.S., Alarico, S., Leal, C. E., Dalgaard, T. L., Empadinhas, N., Carvalho, E., Jenssen, H. (2021)
Molecular Therapy: Medthods & Clinical Development. Read more
Fungal Textiles: Wet spinning of fungal microfibers to produce monofilament yarns
Svensson, S.E., Ferreira, J.A., Hakkarainen, M., Adolfsson, K. H., Zamani, A. (2021)
Sustainable Materials and Technologies. Read more
2020
Minimal nutrient requirements for induction of germination of Aspergillus niger conidia
ljadpanahsaravi, M., Punt, M., Wösten, H.A.B., Teertstra, W.R. (2020)
Fungal Biology 1195. Read more
Susceptibility of dairy associated molds towards microbial metabolites with focus on the response to diacetyl
Shi, C., Knøchel, S. (2020)
Food Control 21, 121. Read more
Optical microscopy reveals the dynamic nature of B. pseudomallei morphology during β-lactam antimicrobial susceptibility testing
McLaughlin, H.P., Bugrysheva, J., & Sue, D. (2020).
BMC Microbiol 20, 209. Read more
Monitoring cell endocytosis of liposomes by real-time electrical impedance spectroscopy
Caviglia, C., Garbarino, F., Canali, C., Melander, F., Raiteri, R., Ferrari, G., … & Emnéus, J. (2020).
Analytical and Bioanalytical Chemistry, 1-10. Read more
Hybrid machine learning assisted modelling framework for particle processes
Nielsen, R. F., Nazemzadeh, N., Sillesen, L. W., Andersson, M. P., Gernaey, K. V., & Mansouri, S. S. (2020).
Computers & Chemical Engineering, 106916. Read more
How preclinical infection models help define antibiotic doses in the clinic
Tängdén, T., Lundberg, C. V., Friberg, L. E., & Huttner, A. (2020).
International Journal of Antimicrobial Agents, 106008. Read more
Current and near-future technologies for antibiotic susceptibility testing and resistant bacteria detection
Dietvorst, J., Vilaplana, L., Uria, N., Marco, M. P., & Muñoz-Berbel, X. (2020).
TrAC Trends in Analytical Chemistry, 115891. Read more
Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
Wistrand-Yuen, P., Olsson, A., Skarp, K., Friberg, L. E., Nielsen, E. I., Lagerbäck, P., & Tängdén, T. (2020).
Clinical Microbiology and Infection. Read more
Evaluation of the efficacy of antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa in automated time-lapse microscopy and static time-kill experiments
Olsson, A., Wistrand-Yuen, P., Nielsen, E. I., Friberg, L. E., Sandegren, L., Lagerbäck, P., & Tängdén, T. (2020).
Antimicrobial Agents and Chemotherapy. Read more
Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria
Wassmann, C.S., Højrup, P. & Klitgaard, J.K. (2020)
Scientific reports 10, 4112. Read more
Insights Obtained by Culturing Saccharibacteria With Their Bacterial Hosts
Bor, B., Collins, A. J., Murugkar, P. P., Balasubramanian, S., To, T. T., Hendrickson, E. L., … & McLean, J. S. (2020).
Journal of Dental Research, 0022034520905792. Read more
Screening for double carbapenem therapies effective against multidrug resistant Enterobacteriaceae
Vickberg, K. (2019)
Master thesis, Uppsala University, Department of Medical Biochemistry and Microbiology. Read more
Bacterial Flow Cytometry and Imaging as Potential Process Monitoring Tools for Industrial Biotechnology
Narayana, S. K., Mallick, S., Siegumfeldt, H., & van den Berg, F. (2020).
Fermentation, 6(1), 10. Read more
2019
Growth and single cell kinetics of the loricate choanoflagellate Diaphanoeca grandis
Eriksen, N. T., Tophøj, J., Wollenberg, R. D., Sondergaard, T. E., Funch, P., & Andersen, P. (2019).
Scientific reports, 9(1), 1-12. Read more
Evaluation of the inhibitory effect of alginate oligosaccharide on yeast and mould in yoghurt
Bouillon, G., Gåserød, O., & Rattray, F. P. (2019).
International Dairy Journal. Read more
The most heat‐resistant conidia observed to date are formed by distinct strains of Paecilomyces variotii
van den Brule, T., Punt, M., Teertstra, W., Houbraken, J., Wösten, H., & Dijksterhuis, J. (2019).
Environmental microbiology. Read more
Immunomodulatory potential of Nisin A with application in wound healing
Mouritzen, M. V., Andrea, A., Qvist, K., Poulsen, S. S., & Jenssen, H. (2019).
Wound Repair and Regeneration. Read more
Fusaoctaxin A, an example of a two-step mechanism for non-ribosomal peptide assembly and maturation in fungi
Westphal, K. R., Nielsen, K. A. H., Wollenberg, R. D., Møllehøj, M. B., Bachleitner, S., Studt, L., … & Sondergaard, T. E. (2019).
Toxins, 11(5), 277. Read more
KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma
Mousavi, N., Truelsen, S. L. B., Hagel, G., Jorgensen, L. N., Harling, H., Timmermans, V., … & Thastrup, J. (2019).
International journal of experimental pathology. Read more
Advances in Rapid Detection and Antimicrobial Susceptibility Tests: A Review
Mishra, P., Mishra, K. P., Singh, D., Ganju, L., Kumar, B., & Singh, S. B. (2019).
Defence Life Science Journal, 4(1), 12-20. Read more
2018
In Vitro Interaction Between Macrophages And Cubosomes For Oral Vaccine Delivery Imaged By Coherent Anti-stokes Raman Scattering (CARS) And Automated Microscopy
Nielsen, L. H., Bargholz, M. T., Saarinen, J., von Halling Laier, C., Ilchenko, O., Isomäki, A. O., … & Strachan, C. J. (2018).
In Controlled Release Society Annual Meeting & Exposition 2018. Read more
Rapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screening
McLaughlin, H. P., & Sue, D. (2018).
BMC microbiology, 18(1), 218. Read more
Analysis of Whole-Genome Sequences for the Prediction of Penicillin Resistance and β-Lactamase Activity in Bacillus anthracis
Gargis, A. S., McLaughlin, H. P., Conley, A. B., Lascols, C., Michel, P. A., Gee, J. E., … & Weigel, L. M. (2018).
mSystems, 3(6), e00154-18. Read more
Phenotypic antibiotic susceptibility testing of pathogenic bacteria using photonic readout methods: recent achievements and impact
Tannert, A., Grohs, R., Popp, J., & Neugebauer, U. (2018).
Applied Microbiology and Biotechnology, 1-18. Read more
Innovations in Antimicrobial Stewardship
Bal, A. M., & Gould, I. M. (2018).
In Advanced Techniques in Diagnostic Microbiology (pp. 699-710). Springer, Cham. Read more
FlbA-regulated gene rpnR is involved in stress resistance and impacts protein secretion when Aspergillus niger is grown on xylose
Aerts, D., van den Bergh, S. G., Post, H., Altelaar, M. A., Arentshorst, M., Ram, A. F., Ohm, R. A., & Wösten, H. A. (2018).
Appl. Environ. Microbiol., AEM-02282. Read more
Advances in online methods for monitoring microbial growth.
Zhang, X., Jiang, X., Hao, Z., & Qu, K. (2018).
Biosensors and Bioelectronics. Read more
Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.
Ashley, N., Ouaret, D., & Bodmer, W. F. (2018).
The Journal of pathology. Read more
Optimized Scratch Assay for In Vitro Testing of Cell Migration with an Automated Optical Camera.
Mouritzen, M. V., & Jenssen, H. (2018).
JoVE (Journal of Visualized Experiments), (138), e57691-e57691. Read more
Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures.
McNair, L. K., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Garrigues, C., Jäger, A. K., Franzyk, H. & Staerk, D. (2018).
FEMS Yeast Research. Read more
Molecular mechanisms of thioridazine resistance in Staphylococcus aureus
Wassmann, C. S., Lund, L. C., Thorsing, M., Lauritzen, S. P., Kolmos, H. J., Kallipolitis, B. H., & Klitgaard, J. K. (2018).
PloS one, 13(8), e0201767. Read more
Quorum Sensing Modulates the Epibiotic-Parasitic Relationship Between Actinomyces odontolyticus and Its Saccharibacteria epibiont, a Nanosynbacter lyticus Strain, TM7x
Bedree, J. K., Bor, B., Cen, L., Edlund, A., Lux, R., McLean, J. S., Shi, W., & He, X. (2018).
Frontiers in microbiology, 9. Read more
Identification and antibiotic‐susceptibility profiling of infectious bacterial agents: a review of current and future trends
Maugeri, G., Lychko, I., Sobral, R., & Roque, A. C. A. (2018).
Biotechnology journal, 1700750. Read more
Combined detection of C-reactive protein and PBMC quantification from whole blood in an integrated lab-on-a-disc microfluidic platform
Uddin, R., Donolato, M., Hwu, E. T., Hansen, M. F., & Boisen, A. (2018).
Sensors and Actuators B: Chemical. Read more
In vitro methods to assess drug precipitation in the fasted small intestine–a PEARRL review
O’Dwyer, P. J., Litou, C., Box, K. J., Dressman, J. B., Kostewicz, E. S., Kuentz, M., & Reppas, C. (2018).
Journal of Pharmacy and Pharmacology. Read more
Neurotensin, substance P, and insulin enhance cell migration.
Mouritzen, M. V., Abourayale, S., Ejaz, R., Ardon, C. B., Carvalho, E., Dalgaard, L. T., Roursgaard, M., & Jenssen, H. (2018).
Journal of Peptide Science, e3093. Read more
LL‐37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line
Saporito, P., Vang Mouritzen, M., Løbner‐Olesen, A., & Jenssen, H. (2018).
Journal of Peptide Science, e3080 Read more
Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids
van der Hee, B., Loonen, L. M. P., Taverne, N., Taverne-Thiele, J. J., Smidt, H., & Wells, J. M. (2018).
Stem Cell Research Read more
Real-Time Digital Bright Field Technology for Rapid Antibiotic Susceptibility Testing
Canali, C., Spillum, E., Valvik, M., Agersnap, N., & Olesen, T. (2018).
Antibiotic Resistance Protocols (pp. 75-84). Humana Press, New York, NY Read more
2017
Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH.
Kristensen, M., Nielsen, L. H., Zór, K., Boisen, A., Christensen, M. V., Berthelsen, J., & Mørck Nielsen, H. (2017).
Bioconjugate Chemistry. Read more
The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.
Christiansen, S. H., Murphy, R. A., Juul-Madsen, K., Fredborg, M., Hvam, M. L., Axelgaard, E., … & Nyengaard, J. R. (2017).
Scientific Reports, 7(1), 15653. Read more
Combining diagnostic methods for antimicrobial susceptibility testing–A comparative approach
Kłodzińska, S. N., Priemel, P. A., Rades, T., & Nielsen, H. M. (2017).
Journal of Microbiological Methods. Read more
Automated time-lapse microscopy a novel method for screening of antibiotic combination effects against multidrug-resistant Gram-negative bacteria.
Ungphakorn, W., Lagerbäck, P., Nielsen, E. I., & Tängdén, T. (2017).
Clinical Microbiology and Infection. Read more
Imaging for monitoring downstream processing of fermentation broths.
Moiseyenko, R., Baum, A., Jørgensen, T. M., Glanville, S., Laursen, C. N., Mansouri, S. S., & Gernaey, K. V. (2017).
In Recent Advances in Fermentation Technology (RAFT 2017). Read more
Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine.
Jeppesen, M., Hagel, G., Glenthoj, A., Vainer, B., Ibsen, P., Harling, H., Thastrup, O., Jørgensen, L. & Thastrup, J. (2017).
PloS one. Read more
Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing.
Li, Y., Yang, X., & Zhao, W. (2017).
SLAS TECHNOLOGY: Translating Life Sciences Innovation. Read more
New evidence for the mechanism of action of a type-2 diabetes drug using a magnetic bead-based automated biosensing platform.
Uddin, R., Habiba, N. E., Rena, G., Hwu, E. T., & Boisen, A. (2017).
ACS sensors. Read more
Development of a video-microscopic tool to evaluate the precipitation kinetics of poorly-water soluble drugs: A case study with tadalafil and HPMC
Christfort, J. F., Plum, J., Madsen, C. M., Nielsen, L. H., Sandau, M., Andersen, K., Müllertz, A., & Rades, T. (2017).
Molecular Pharmaceutics. Read more
Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci
Rasmussen, K. S., Poulsen, M. Ø., Jacobsen, K., Skov, M. N., Kolmos, H. J., Kallipolitis, B. H., & Klitgaard, J. K. (2017).
The new microbiologica, 40(2). Read more
Synergistic activities of meropenem double and triple combinations against carbapenemase-producing Enterobacteriaceae
Fredborg, M., Sondergaard, T. E., & Wang, M. (2017).
Diagnostic Microbiology and Infectious Disease. Read more
Optical screening for rapid antimicrobial susceptibility testing and for observation of phenotypic diversity among strains of the genetically clonal species Bacillus anthracis
McLaughlin HP, Gargis AS, Michel P, Sue D, Weigel LM. (2017).
J Clin Microbiol 55:959–970. Read more
New and developing diagnostic technologies for urinary tract infections
Davenport, M., Mach, K. E., Shortliffe, L. M. D., Banaei, N., Wang, T. H., & Liao, J. C. (2017).
Nature Reviews Urology. Read more:
Current and emerging techniques for antibiotic susceptibility tests
Syal K, Mo M, Yu H, Iriya R, Jing W, Guodong S, Wang S, Grys TE, Haydel SE, Tao N.
Theranostics 2017; 7(7):1795-1805. Read more:
Maturation of conidia on conidiophores of Aspergillus niger
Teertstra, W. R., Tegelaar, M., Dijksterhuis, J., Golovina, E. A., Ohm, R. A., & Wösten, H. A. (2017).
Fungal Genetics and Biology, 98, 61-70. Read more:
Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics
Ungphakorn, W., Malmberg, C., Lagerbäck, P., Cars, O., Nielsen, E. I., & Tängdén, T. (2017).
Journal of Microbiological Methods, 132, 69-75. Read more:
2016
Fast Screening of Antibacterial Compounds from Fusaria
Sondergaard, T. E., Fredborg, M., Oppenhagen Christensen, A. M., Damsgaard, S. K., Kramer, N. F., Giese, H., & Sørensen, J. L. (2016).
Toxins, 8(12), 355. Read more:
Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium
Wollenberg, R. D., Donau, S. S., Nielsen, T. T., Sørensen, J. L., Giese, H., Wimmer, R., & Søndergaard, T. E. (2016).
Pesticide Biochemistry and Physiology, 134, 24-30. Read more:
Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture
Pijuan-Galitó, S., Tamm, C., Schuster, J., Sobol, M., Forsberg, L., Merry, C. L., & Annerén, C. (2016).
Nature Communications, 7: 12170. Read more:
Lab-on-a-disc agglutination assay for protein detection by optomagnetic readout and optical imaging using nano-and micro-sized magnetic beads
Uddin, R., Burger, R., Donolato, M., Fock, J., Creagh, M., Hansen, M. F., & Boisen, A. (2016).
Biosensors and Bioelectronics, 85, 351-357. Read more:
The In Vitro Redundant Enzymes PurN and PurT are both essential for systemic infection of mice in Salmonella enterica serovar Typhimurium
Jelsbak, L., Mortensen, M. I., Kilstrup, M., & Olsen, J. E. (2016).
Infection and immunity, 84(7), 2076-2085. Read more:
2015
Integration of agglutination assay for protein detection in microfluidic disc using Blu-ray optical pickup unit and optical fluid scanning
Uddin, R., Burger, R., Donolato, M., Fock, J., Creagh, M., Hansen, M. F., & Boisen, A. (2015).
Proceedings of Microtas 2015, Gyeongju, Korea. Read more:
Real-time monitoring of fungal inhibition and morphological changes
Aunsbjerg, S. D., Andersen, K. R., & Knøchel, S. (2015).
Journal of microbiological methods, 119, 196-202. Read more:
Automated image analysis for quantification of filamentous bacteria
Fredborg, M., Rosenvinge, F. S., Spillum, E., Kroghsbo, S., Wang, M., & Sondergaard, T. E. (2015).
BMC microbiology, 15(1), 255. Read more:
Rapid antimicrobial susceptibility testing of clinical isolates by digital time-lapse microscopy
Fredborg, M., Rosenvinge, F. S., Spillum, E., Kroghsbo, S., Wang, M., & Sondergaard, T. E. (2015).
European Journal of Clinical Microbiology & Infectious Diseases, 34(12), 2385-2394. Read more:
Extended spectrum β-lactamase-producing E. coli forms filaments as an initial response to cefotaxime treatment
Kjeldsen, T. S., Sommer, M. O., & Olsen, J. E. (2015).
BMC microbiology, 15(1), 63. Read more:
Rational design of Alpha-Helical Antimicrobial Peptides: Dos and Don’ts
Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt‐Moller, N., Hansen, P. R., & Wimmer, R. (2015).
ChemBioChem, 16(2), 242-253. Read more:
A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants
Khan, D. D., Lagerbäck, P., Cao, S., Lustig, U., Nielsen, E. I., Cars, O., Hughes, D., Andersson, D. I., & Friberg, L. E. (2015).
Journal of Antimicrobial Chemotherapy, 70(11), 3051-3060. Read more:
2014
Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays
Ashley, N., Jones, M., Ouaret, D., Wilding, J., & Bodmer, W. F. (2014).
The Journal of pathology, 234(1), 34-45. Read more:
Complete sequences of IncHI1 plasmids carrying blaCTX-M-1 and qnrS1 in equine Escherichia coli provide new insights into plasmid evolution
Dolejska, M., Villa, L., Minoia, M., Guardabassi, L., & Carattoli, A. (2014)
Journal of Antimicrobial Chemotherapy, 69(9): 2388-93. Read more:
Identification of the Biosynthetic Gene Clusters for the Lipopeptides Fusaristatin A and W493 B in Fusarium graminearum and F. pseudograminearum
Sørensen, J. L., Sondergaard, T. E., Covarelli, L., Fuertes, P. R., Hansen, F. T., Frandsen, R. J. N., Saei, W., Lukassen, M. B., Wimmer, R., Nielsen, K. F., Gardiner, D. M., & Giese, H. (2014)
Journal of natural products, 77(12), 2619-2625. Read more:
2013
Real-time optical antimicrobial susceptibility testing
Fredborg, M., Andersen, K. R., Jørgensen, E., Droce, A., Olesen, T., Jensen, B. B., Rosenvinge, F. S., & Sondergaard, T. E. (2013)
Journal of clinical microbiology, 51(7), 2047-2053. Read more:
