oCelloScope – Automated Microbial Live-Cell Imaging and Analysis 

Speed

  • 250 times more sensitive than a plate reader (OD)
  • Measure and visualize down to 5 x 103 CFU/ml
  • Growth kinetic MIC results in few hours Vs 16-20h using BMD
  • FluidScope technology scans a full 96-well plate in less than 3 minutes
null

Early phase morphology

  • Compare growth kinetic curves with images from each time-point 
  • Discover microorganism adaptation strategies
  • Capture and quantify morphological changes over time
  • Spheroplasts, Filamentation, Co-aggregation, Fungal spore germination  

Value

  • Full flexibility – use your standard microtiter plates
  • You get full software package to use on multiple PC’s 
  • No expensive annual service contract   
  • Competitive pricing. Rent or Purchase – just ask for a quotation

Meet Our User Network

AMR – Antimicrobial Resistance

4 times faster than Broth Microdilution (BMD)

The oCelloScope is used by AMR researchers all over the world, including the US CDC to test new or existing drugs against resistant microorganisms.

 

..”All optical screening results were consistent with results from conventional susceptibility tests and were available in 4 h. This decreased the time required to determine antimicrobial susceptibility profiles by 75 to 80%, as conventional testing by BMD requires sufficient visible growth for interpretation of results and has been standardized by CLSI as a 16- to 20-h incubation time for B. anthracis.” McLaughlin, H.P., Gargis, A.S., Michel, P., Sue, D., and Weigel, L.M. (2017). J. Clin. Microbiol. 55, 959–970.

 

The software interface is intuitive and we typically only need a one hour web intro to get you started. Two modules are primarily used in AMR research – Growth Kinetics and Segmentation. Growth Kinetics is used to screen bacterial or fungal strains for resistance patterns in high throughput. The Segmentation module will take you a step deeper and enable you to analyze and quantify morphological responses. 

Follow the β-lactam-induced cell morphology changes

The UniExplorer image analysis software enables you to get deeper insights into your sample dynamics, as changes on single cell level can be quantified.

 

Left: Segmentation analysis of Acinetobacter haemolyticus treated with Imipenem. Spheroplasts are detected using image analysis and counted automatically as a function of time.

Pull lever left or right to see the power of image analysis.

Read more

Food Microbiology

Fungal spore treatment and germination pattern (Aspergillus niger)

Time-lapse movie of Aspergillus niger

The oCelloScope for food microbiology enable you to analyze up to 96 microbial samples in real time. The higher sensitivity and the ability to monitor and analyze cellular morphology makes the oCelloScope superior to using a microplate reader. Today, researchers in Food Microbiology use the oCelloScope in: Preservatives Discovery, Screening of Probiotics, Sanitizer Development, Cheese Development, Yeast Discovery, Beverage Batch Release Testing, Food Molds and Fungal Spore Development.

Co-culture challenges in food microbiology

The UniExplorer image analysis software enables you to analyze Co-culture samples and discriminate between different species.    

 

Right: Co-culture study of Lactobacillus and Yeast (Saccharomyces cerevisiae). Image analysis is used to measure inhibitory effects of Lactobacillus. Yeast growth morphological characteristics such as size, chain length and number of clusters can be monitored over time.

Pull lever left or right to see the power of image analysis.

Read more

oCelloScope Inspiration

Escherichia coli growth time-lapse captured with oCelloScope: (left) non-treated control , (right) treated with 0.12µg/ml Imipenem: spheroplast formation and cell lysis is observed upon treatment. Starting cell concentration 105 cell/ml.

Pseudomonas aeruginosa growth time-lapse captured with oCelloScope: (left) non-treated control, (right) treated with 0.5µg/ml of Ceftazidime: Filamentation is observed as a consequence of antibiotic treatment. Starting cell concentration 105 cell/ml.

Time-Lapse of PC12 Rat adrenal medulla cells. Field of view 0.6mm x 1.4mm. 

Pharmaceutical research. Zebrafish, 72h embryo development. Dep of Veterinary and Animal Sciences, University of Copenhagen.

Fisheries Research. Ichtyophterius multifilis, Dep of Veterinary and Animal Sciences, University of Copenhagen.

Want to talk Science

or get a Quotation?

CALL US

Direct: (+45) 26 28 19 43
Sales: (+45) 22 30 84 00

MAIL

Info@biosensesolutions.dk

LOCATION

Hirsemarken 1
3520 Farum
Denmark

BUSINESS HOURS

Monday to Friday: 8 am – 5 pm

Send message